Pharmaceutical Science

Classes

PHSC-302 : Research in Pharmaceutical Sciences

The course deals with an introduction to techniques and methodologies in pharmaceutical sciences research. Emphasis on literature retrieval, design/conduct of experiments on a specific problem, analysis and interpretation of data for a written report.

Credits

Credits 3

Prerequisites

All Department of Pharmaceutical Sciences Courses in the first-year (fall and spring); minimum cumulative GPA of 2.75; and, permission of the instructor.

PHSC-307 : Pharmaceutics

The design of the course is based on the integration of the study of physicochemical principles of pharmacy with formulation and preparation of pharmaceutical dosage forms. The integration is done within each main class of pharmaceutical dosage forms. The study of the physicochemical principles of pharmacy serves as a prologue to the materials covered in each section. Then the application of the knowledge of the physicochemical principles of pharmacy to the rational formulation, preparation/compounding, quality control, stability, packaging and storage of pharmaceutical dosage forms follows directly after the study of the physicochemical principles for each module (i.e., each major class of dosage forms).

Credits

Credits 4

PHSC-308 : Pharmacological Therapeutics II

This is a continuation of Pharmacological Therapeutics I. The course deals with the study and application of physico-chemical properties and the relationship between chemical structure and pharmacological activities of organic medicinal agents of natural and synthetic origin.

Credits

Credits 3

PHSC-309 : Pharmaceutical Chemistry II

This is a continuation of Pharmaceutical Chemistry I. The course deals with the study and application of physico-chemical properties and the relationship between chemical structure and pharmacological activities of organic medicinal agents of natural and synthetic origin.

Credits

Credits 3

PHSC-312 : Pharmacological Therapeutics I

The course deals with the study and application of physico-chemical properties and the relationship between chemical structure and pharmacological activities of organic medicinal agents of natural and synthetic origin

Credits

Credits 3

PHSC-313 : Pharmaceutical Calculations II

This course is the continuation of Pharmaceutical Calculation I course. Quantitative skills necessary for an understanding of the 37 basic and clinical pharmaceutical sciences will be explored. Various techniques necessary in pharmaceutical calculations employed by the pharmacist in formulation, compounding, manufacturing and dispensing of medications will be discussed. The course will also provide the student with the development of skills to recognize errors in prescribing in both oral and written medication orders, basic patient and professional staff communication and basic patient data collection skill. Commonly used equipment and pharmaceutical dosing devices available in a variety of simulated practice settings will be introduced.

Credits

Credits 2

PHSC-314 : Pharmacokinetics

At the end of the course, the student should have acquired competency in the selection, design and adjustment of drug dosing regimens to optimize patient therapy on the basis of the patient's age and disease condition and the drug's pharmacokinetic and pharmacodynamic properties. Special emphasis is placed on those drugs with narrow therapeutic windows, which require therapeutic monitoring.

Credits

Credits 4

Prerequisites

Biopharmaceutics

PHSC-315 : Pharmaceutical Chemistry I

The course deals with the study and application of physico-chemical properties and the relationship between chemical structure and pharmacological activities of organic medicinal agents of natural and synthetic origin.

Credits

Credits 3

PHSC-316 : Physico-chemical Principles of Pharmacy

Drug action is dependent on a range of physico-chemical principles. These relate not only to the drug substance, or active pharmaceutical ingredient, but also to the excipients used in the production of the dosage form. An understanding of these physico-chemical principles affords a better understanding of drug action, and an appreciation of the factors that may influence such drug action. Course work and laboratory exercises relating to physico-chemical principles are not part of the pharmacy curriculum since the emphasis is on the clinical aspects. However, this course has been designed to provide a basic understanding of the factors involved. Various examples will be discussed during class time which may, in some instances, also include a laboratory demonstration. The latter affords students the opportunity to observe certain effects where physico-chemical principles play a role.

Credits

Credits 2

PHSC-317 : Structures & Functions in Therapeutics

This course is designed to provide the student with the fundamental knowledge of the general structure and function of the human body. A short introduction to basic cell structure, tissues, human development and physiological control mechanisms & membrane transport is given at the beginning of the course to help the student acquire a better understanding of human anatomy and physiology. Instruction using the systemic approach has been adopted for this course. This method provides a better correlation among the tissues and organs and their functions of a particular system and between the systems themselves. A systemic approach also promotes the understanding of structure and function of the human body. The lectures are designed to give the student fundamental and essential knowledge of the human body's various organ systems. Slide projections, power point presentations, computer simulations and lecture outlines are used as teaching aids in this course. Work in the laboratory provides students with the opportunity to study prosecuted cadaver materials, anatomical models and physiological applications. Students are further guided by printed laboratory organization and objectives.

Credits

Credits 2

PHSC-319 : Making Medicines

The Process of Drug Development is an innovative, eLearning course geared toward students with an interest in health and science fields with an emphasis on gaining knowledge in the area of medical research.

Credits

Credits 3

PHSC-320 : Anions and Cations in Biological Systems

The course deals with the study and application of physico-chemical properties and the relationship between chemical structure and pharmacological activities of inorganic medicinal agents.

Credits

Credits 3

Prerequisites

Pharmaceutical Chemistry I and Pharmacological Therapeutics I.

PHSC-321 : Applications for Pharmacy Practice

The course will be co-coordinated by clinical and basic science faculty, who will provide instruction utilizing both didactic and practical teaching modalities. The applications for pharmacy practice I course is the first in a longitudinal series of courses meant to fully integrate knowledge and skills acquired from each course running during the same semester. It aims to incorporate the entrustable professional activities (EPAs), which emphasize practical applications for being a clinical pharmacist, using interactive and case-based learning activities during scheduled 3-hour sessions. Students will learn the purpose of the material taught in each course as well as how that material may be applied in practice-based real-world scenarios.

Credits

Credits 1

PHSC-323 : Pharm Calculations I

Quantitative skills necessary for an understanding of the 37 basic and clinical pharmaceutical sciences will be explored. Various techniques necessary in pharmaceutical calculations employed by the pharmacist in formulation, compounding, manufacturing and dispensing of medications will be discussed. The course will also provide the student with the development of skills to recognize errors in prescribing in both oral and written medication orders, basic patient and professional staff communication and basic patient data collection skill. Commonly used equipment and pharmaceutical dosing devices available in a variety of simulated practice settings will be introduced.

Credits

Credits 2

PHSC-325 : New Informatics Technologies in Pharmacy

Virtual Reality (VR), Augmented Reality (AR), and Artificial Intelligence (AI) have been broad and fast-growing subfields of Informatics Technologies in recent years. We've heard all the media buzz, so what are the science, technology, and art issues to building these immersive and compelling experiences? And what are the impacts of those powerful techniques on traditional healthcare businesses, especially the Pharmacy as a profession? This course provides an overview of history, methods, and applications of VR, AR and AI. It covers current topics of hardware, software, interaction, psychology, algorithms (particularly machine learning), problem solving, and research that are involved in those technologies. In addition to the lectures, there will be course projects that the user will build their own virtual environments in Pharmacy settings, using novel interface and display devices. The apps and sample codes will be provided. However, the lectures will not provide any support to completing the projects, but rather to complement the learning. In the end, this course will inform the way the PharmD students can approach and contribute to those emerging technologies, thus prepare them well for the future development.

Credits

Credits 3

Prerequisites

None

PHSC-336 : Pharm Compounding Lab

The application of the knowledge of Physico-chemical principles to the formulation, compounding, quality control and storage of pharmaceutical dosage forms.

Credits

Credits 2

Prerequisites

Pharmaceutics.

PHSC-347 : Applications for Pharmacy Practice 2

This is a continuation of Application in Pharmacy Practice I course. The course will be co-coordinated by clinical and basic science faculty, who will provide instruction utilizing both didactic and practical teaching modalities. The applications for pharmacy practice I course is the first in a longitudinal series of courses meant to fully integrate knowledge and skills acquired from each course running during the same semester. It aims to incorporate the entrustable professional activities (EPAs), which emphasize practical applications for being a clinical pharmacist, using interactive and case-based learning activities during scheduled 3-hour sessions. Students will learn the purpose of the material taught in each course as well as how that material may be applied in practice-based real-world scenarios.

Credits

Credits 1

PHSC-373 : Applications for Pharmacy Practice 4

This is a continuation of Application in Pharmacy Practice 3 course. The course will be co-coordinated by clinical and basic science faculty, who will provide instruction utilizing both didactic and practical teaching modalities. The applications for pharmacy practice 4 course is the fourth in a longitudinal series of courses meant to fully integrate knowledge and skills acquired from each course running during the same semester. It aims to incorporate the entrustable professional activities (EPAs), which emphasize practical applications for being a clinical pharmacist, using interactive and case-based learning activities during scheduled 3-hour sessions. Students will learn the purpose of the material taught in each course as well as how that material may be applied in practice-based real-world scenarios.CL

Credits

Credits 1

PHSC-398 : Advanced Biopharmaceutics

This course provides the student with a practical understanding of the principles of biopharmaceutics that can be applied to drug product development and drug therapy. This course remains unique in teaching basic concepts that may be applied to understanding complex issues associated with in vivo drug delivery that are essential for safe and efficacious drug therapy.

Credits

Credits 3

PHSC-401 : Research Rotation

The purpose of this class is to work with faculty to conduct/prepare for elective course/research.

Credits

Credits 3

PHSC-410 : Applied Pharmacokinetics

Pharmacokinetics describe "what the body does to a drug" and thus is a central feature of applied pharmacology. The course will develop an understanding of the role that pharmacokinetics play in all aspects of drug administration, distribution, metabolism and excretion and how these effects can be modelled and predicted graphically and mathematically. Such modelling is a fundament of therapeutic regimen design, drug development, clinical pharmacology and drug safety and will be considered within all of these contexts providing a broad and relevant appreciation of the importance of pharmacokinetics to the Pharmaceutical Scientist

Credits

Credits 3

PHSC-422 : Drug Design in Pharmaceutical Sciences

This course covers the basic principles of how new drugs are discovered with emphasis on lead identification, lead optimization, classification and kinetics of molecules targeting enzymes and receptors, prodrug design and applications, as well as structure-based drug design methods.

Credits

Credits 3

PHSC-423 : Advances in Drug Delivery Systems

This course addresses Novel Drug delivery System (NDDS). It addresses the approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effects. NDDS is a system for delivery of drugs other than conventional drug delivery systems. NDDS is a combination of advance technique and new dosage forms which are far better than conventional dosage forms.

Credits

Credits 3

PHSC-425 : Organometalic Chemistry in Drug Synthesis

This course is designed to introduce the students to the advanced concepts of organometallic chemistry and its applications towards the synthesis of biologically interesting compounds, such as drugs and druglike molecules. The course will emphasize the underlying principles of reactivity, transition state analysis, name reactions and applications in heterocyclic chemistry.

Credits

Credits 3

PHSC-429 : Biopharmaceutics

This course discusses basic concepts in pharmacokinetics (kinetics of drug absorption, distribution and elimination); bioavailability (rate and extent of absorption); influence of physicochemical, formulation, physiologic and disease variables on pharmacokinetics and bioavailability; and rationale for drug and dosage selection and monitoring in patient care.

Credits

Credits 3

Prerequisites

Pharmaceutical Chemistry I&II, Pharmacological Therapeutics I&II, Pharmaceutics and Physico-chemical principles of pharmacy.

PHSC-430 : Advanced Pharmacy Administration

This is a core course within the pharmacy administration track and requires successful completion of Principles of Pharmacy Care Management, Biostatistics and Research Methods, Research Design and Methods and Pharmacoepidemiology prerequisites for enrollment. This course will first introduce them to the history of pharmacy administration, then introduce them to skills on critiquing pharmacoeconomics articles and then introduce them to advanced topics in the field of pharmacy administration. Students will also be required to perform a systematic review on a topic of their choosing and submit the work for publication in a scientific journal. In addition, the student will perform presentations on various topics.

Credits

Credits 3

PHSC-434 : Pharm Care Organizational Management

This course is an expansive and in-depth Introduction to Pharmacy Care Management and Pharmacy Administration. It facilitates the student's management and leadership training by introducing them to a comprehensive overview of management and leadership principles, concepts and practices in pharmacy based environments. The course further addresses the economic, administrative and human aspects of pharmacy practice while introducing students to details about the US HealthCare System and the specific roles of pharmacists.

Credits

Credits 3

PHSC-438 : Applications for Pharmacy Practice 3

This is a continuation of Application in Pharmacy Practice 2 course. The course will be co-coordinated by clinical and basic science faculty, who will provide instruction utilizing both didactic and practical teaching modalities. The applications for pharmacy practice 3 course is the third in a longitudinal series of courses meant to fully integrate knowledge and skills acquired from each course running during the same semester. It aims to incorporate the entrustable professional activities (EPAs), which emphasize practical applications for being a clinical pharmacist, using interactive and case-based learning activities during scheduled 3-hour sessions. Students will learn the purpose of the material taught in each course as well as how that material may be applied in practice-based real-world scenarios.

Credits

Credits 1

PHSC-509 : Principles of Drug Formulation

The course is based on basic knowledge within the pharmaceutics and broadens and deepens the knowledge regarding formulation and production especially of solid preparations in aim to prepare the students for experimental scientific work and industrial pharmaceutical activities within this topic of pharmaceutics. In the course, the following subject matter is treated: Characterization of the physical properties of solid material: Solid-state analysis, particle size analysis and particle statistics, form analysis, form factors, surface and pore-size analysis, analysis of mechanical properties and transmission at and modelling of the compression process. Formulation principles of controlled/optimized releasement and absorption of drugs: Systems for nasal, pulmonary and cutaneous drug administration and basic physiological aspects for pharmaceutical formulation. Formulation, stabilization and lyophilization of protein-targeted drugs and optimized administration of these

Credits

Credits 3

PHSC-511 : Biostatistics

This course introduces the biostatistics methods and their application of statistics in biology and biomedical science.

Credits

Credits 4

PHSC-523 : Molecular Modeling

The course includes 4 units teachings on computational chemistry, molecular modeling, elements of chemoinformatics, and drug design and discovery. Unit 1 focuses on experimental aspects and computer models of molecules and their behavior in gas and condensed phases; quantum and molecular mechanics etc. Unit 2 focuses on molecular modeling which includes ligand-based Drug Design, Quantitative structure-activity relationships (QSAR)- Introduction of Molecular Descriptors (1D,2D and 3D), Statistical analysis- Linear and Nonlinear Methods etc. Unit 3 focuses on history of chemoinformatics, definition of chemoinformatics, chemical structure representation as well as introduction to chemical structure file formats etc. Lastly, Unit 4 focuses on drug design and discovery of contour of Drugs -Development of New Drugs - molecular recognition in drug design- Introduction to molecular diversity etc.

Credits

Credits 3

PHSC-535 : Pharmacoeconomics I

The course will familiarize students with terms, concepts, and methods utilized in pharmacoeconomic research. The advantages and disadvantages of different tools and methods will be discussed. The course will use a variety of teaching strategies including lecture, small and in class discussions. Students will be evaluated using quizzes and will be required to write a paper and do a presentation(s).

Credits

Credits 3

PHSC-537 : Pharmacoepidemiology

The Pharmacoepidemiology and Outcomes Research section is an introduction to the evaluation of the scientific studies that supports the rational use of medication use in humans. The goals of this block is to provide opportunities for students to understand the concepts, methods, and applications of pharmacoepidemiology, pharmacoeconomics, and outcomes studies utilized in clinical settings as well as with to provide tools to critically assess the clinical literature. In addition, the methods for the interpretational and generalization of findings from these studies relevant to medical and pharmaceutical care practice will be introduced by utilizing knowledge developed from the Research Methods/Biostatistics block. Students will be also prepared for problem-based critique sessions in the Integrative Therapeutics blocks.

Credits

Credits 3

PHSC-601 : Seminar

The goal of the course is to expose graduate students in the Department of Pharmaceutical Sciences to the faculty research in our department. Students will be presented with a number of research topics, including pharmaceutics, pharmacokinetics, medicinal chemistry, Pharmacy administration, pharmaceutics, pharmacoepidemiology, pharmacoeconomics, Regulatory Affairs. In addition to the presentations by faculty members, several guest speakers will present their research topics and discuss their opinions on science careers outside of academia (i.e., industry, medical writing, medical science liaison, etc.). Through exposure to these diverse research topics, students will become more well-rounded scientists and become more aware of career opportunities that are available to them

Credits

Credits 2

PHSC-602 : Seminar

The goal of the course is to expose graduate students in the Department of Pharmaceutical Sciences to the faculty research in our department. Students will be presented with a number of research topics, including pharmaceutics, pharmacokinetics, medicinal chemistry, Pharmacy administration, pharmaceutics, pharmacoepidemiology, pharmacoeconomics, Regulatory Affairs. In addition to the presentations by faculty members, several guest speakers will present their research topics and discuss their opinions on science careers outside of academia (i.e., industry, medical writing, medical science liaison, etc.). Through exposure to these diverse research topics, students will become more well-rounded scientists and become more aware of career opportunities that are available to them

Credits

Credits 1

PHSC-604 : Dissertation Writing

Supervised execution of the doctoral dissertation.

Credits

Credits 3

Prerequisites

Successful completion of doctoral qualifying examination and admission to candidacy.

PHSC-609 : Statistical Experimental Design and Optimization

The goal of the course is to expose students to Experimental Design Stages so that they may be able to a) Identify the factors which may affect the results of an experiment; b) Design an experiment so that the effects of uncontrolled factors are minimized; and c) Use statistical analysis to separate and evaluate results.

Credits

Credits 3

PHSC-611 : Advanced Pharmacy Administration II

A continuation of PHSC-430. This is a core course within the pharmacy administration track and requires successful completion of Principles of Pharmacy Care Management, Biostatistics and Research Methods, Research Design and Methods and Pharmacoepidemiology prerequisites for enrollment. This course will first introduce them to the history of pharmacy administration, then introduce them to skills on critiquing pharmacoeconomics articles and then introduce them to advanced topics in the field of pharmacy administration. Students will also be required to perform a systematic review on a topic of their choosing and submit the work for publication in a scientific journal. In addition, the student will perform presentations on various topics.

Credits

Credits 3

PHSC-612 : Pharmacoeconomics II

A continuation of PHSC-535. The course will familiarize students with terms, concepts, and methods utilized in pharmacoeconomic research. The advantages and disadvantages of different tools and methods will be discussed. The course will use a variety of teaching strategies including lecture, small and in class discussions. Students will be evaluated using quizzes and will be required to write a paper and do a presentation(s).

Credits

Credits 3

PHSC-631 : Research Design and Methods

The purpose of this class is to introduce graduate students to the scientific process in research design and methodology for identification, solution and reporting of a specific problem relevant to basic pharmaceutical sciences, social/behavioral, and health services research. Emphasis will be given to acquire skills for literature retrieval and understanding on design of studies, analysis and interpretation of data. Each student will conduct an extensive literature evaluation and do a journal critique and attend relevant workshops in order to be successful in this course.

Credits

Credits 3

PHSC-632 : Advanced Statistics

This course provides an overview of statistical methods for analyzing correlated data produced by longitudinal measurements taken over time. Topics include study design, exploratory data analysis techniques and linear mixed effects regression models.

PHSC-647 : Advanced Physical Pharmacy

This course covers the physical and chemical principles in drug formulation design, with emphasis on such topics as solutions of nonelectrolytes and electrolytes, ionic equilibria, drug complexation, reaction kinetics, mass transport, and interfacial phenomena.

Credits

Credits 3

PHSC-701 : Research

The purpose of this class is to work with faculty to conduct/prepare for elective course/research. See note on page 577 related to research and dissertation hours

Credits

Credits 9

PHSC-702 : Foundations of Cancer Targeting

This course discusses the foundational principles associated with the design and development of delivery systems for passive cancer targeting. As a foundational concept to cancer targeting, the enhanced permeability and retention (EPR) effect is introduced and discussed. All the challenges associated with the EPR effect are discussed and different drug delivery strategies that utilize the EPR effect are described. Additionally, approaches to improve the efficiency of the EPR effect are discussed. Primary literature is the sole resource used in this course and students are encouraged to interact and discuss these principles in a practical manner.

Credits

Credits 3

PHSC-703 : Proposal Writing

This course introduces students to the process of creating a competitive grant proposal. Students critique funding opportunities and develop a project consistent with the Request For Proposal (RFP). Detailed examination of the proposal components are considered, including the narrative, methodology and budget

Credits

Credits 3

PHSC-707 : Cancer Targeting Approaches for Drug Delivery Applications

This course essentially deals with the ways and mechanisms of active targeting to tumors. The different active targeting methods and chemistries used in drug delivery systems/applications are discussed. Specifically, we discuss examples of drug targeting to tumors using the pH differential of the tumor microenvironment and endosomes, drug targeting and release mechanisms via enzymes such as proteases for drug targeting, and selective targeting to receptors overexpressed on the surface of cancer cells. Primary literature is the sole resource used in this course and students are encouraged to interact and discuss these principles in a practical manner.

Credits

Credits 3

PHSC-714 : Drug Stability & Packaging

Governing bodies as well as pharmaceutical companies are paying great attention to the stability of drug products to enable delivery of the products to the final consumer in good quality. Packaging plays a major role in providing stability to the pharmaceutical products. This course discusses factors influencing stability of drugs and the techniques of packaging to maintain stability of the products.

Credits

Credits 3

PHSC-747 : Nano Therapeutics

This course addresses the biomedical applications of nanoparticles and helps students think and become aware be aware of the issues involved in the design of nanoparticles and biomedical applications of nanoparticles. Students learn to anticipate new and novel developments and applications and are urged to think creatively with a future bent.

Credits

Credits 3

PHSC-801 : Dissertation

The purpose of this class is to work with faculty to conduct/prepare research for proposal/dissertation. See note on page 577 related to dissertation hours.

Credits

Credits 9